Whisk together the soy sauce, worcestershire, liquid smoke, brown sugar, salt, pepper, meat tenderizer, garlic powder, onion powder, and paprika. Add meat to sauce and let marinate for about 8 hours.
Remove meat from marinade and pat meat dry with paper towels. Arrange meat in single layers in the air fryer using racks or skeweres to create layers. Air fry at 180°F/82°C for 45 minutes. Check it, then add 15-25 more minutes until it reaches your desired texture. Cook longer for more tough, chewy jerky. (60 minutes total was just about right for me.)